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| |
Origin
|
Final
|
|---|
|
Comparison
|
Group
|
OR (95% CI)
|
Heterogeneity test
|
OR (95% CI)
|
Heterogeneity test
|
|---|
|
P
|
I2
|
P
|
I2
|
|---|
|
Allele model (C versus T)
|
Overall
|
0.83 [0.74, 0.93]
|
<0.00001
|
77%
|
0.79 [0.73, 0.87]
|
0.009
|
54%
|
|
Caucasian
|
0.82 [0.72, 0.93]
|
0.23
|
30%
|
0.82 [0.72, 0.93]
|
0.23
|
30%
|
|
Asian
|
0.83 [0.70, 0.99]
|
<0.00001
|
86%
|
0.78 [0.68, 0.88]
|
0.002
|
69%
|
|
African
|
0.89 [0.59, 1.34]
|
0.39
|
0%
|
0.89 [0.59, 1.34]
|
0.39
|
0%
|
|
Dominant model (CC + CT versus TT)
|
Overall
|
0.78 [0.67, 0.90]
|
<0.00001
|
74%
|
NA
|
|
Caucasian
|
0.74 [0.58, 0.94]
|
0.06
|
59%
|
|
Asian
|
0.79 [0.65, 0.96]
|
<0.00001
|
81%
|
|
African
|
0.86 [0.26, 2.78]
|
0.06
|
72%
|
|
Recessive model (CC versus CT + TT)
|
Overall
|
0.80 [0.65, 0.99]
|
0.0002
|
65%
|
0.76 [0.68, 0.86]
|
0.73
|
0%
|
|
Caucasian
|
0.83 [0.69, 1.00]
|
0.80
|
0%
|
0.83 [0.69, 1.00]
|
0.80
|
0%
|
|
Asian
|
0. 78 [0.55, 1.10]
|
<0.00001
|
79%
|
0.71 [0.60, 0.83]
|
0.52
|
0%
|
|
African
|
0.91 [0.47, 1.76]
|
0.51
|
0%
|
0.91 [0.47, 1.76]
|
0.51
|
0%
|
|
Heterozygous model (CT versus TT)
|
Overall
|
0.79 [0.69, 0.91]
|
<0.0001
|
68%
|
NA
|
|
Caucasian
|
0.75 [0.58, 0.98]
|
0.05
|
62%
|
|
Asian
|
0.80 [0.68, 0.96]
|
0.0003
|
73%
|
|
African
|
0.88 [0.17, 4.46]
|
0.02
|
82%
|
|
Homozygous model (CC versus TT)
|
Overall
|
0.70 [0.55, 0.90]
|
<0.00001
|
72%
|
0.66 [0.58, 0.76]
|
0.39
|
6%
|
|
Caucasian
|
0.73 [0.60, 0.89]
|
0.54
|
0%
|
0.73 [0.60, 0.89]
|
0.54
|
0%
|
|
Asian
|
0.69 [0.47, 1.03]
|
<0.00001
|
83%
|
0.61 [0.50, 0.74]
|
0.22
|
26%
|
|
African
|
0.81 [0.38, 1.72]
|
0.54
|
0%
|
0.81 [0.38, 1.72]
|
0.54
|
0%
|
