Table 4 GRADE evidence evaluation
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | |
|---|---|---|---|---|---|
| Assumed risk | Corresponding risk | ||||
| Control | SNP | ||||
| C versus T | Study population | OR 0.78 (0.72 to 0.84) | 24,756 (13 studies) | ⊕ ⊕ ⊝ ⊝ Low | |
| 349 per 1000 | 295 per 1000 (279 to 311) | ||||
| Moderate | |||||
| 391 per 1000 | 334 per 1000 (316 to 350) | ||||
| CC versus CT + TT | Study population | OR 0.76 (0.68 to 0.86) | 14,839 (14 studies) | ⊕ ⊕ ⊝ ⊝ Low | |
| 116 per 1000 | 91 per 1000 (82 to 101) | ||||
| Moderate | |||||
| 153 per 1000 | 121 per 1000 (109 to 134) | ||||
| CC versus TT | Study population | OR 0.66 (0.58 to 0.76) |
8629 (14 studies) | ⊕ ⊕ ⊝ ⊝ Low | |
| 205 per 1000 | 145 per 1000 (130 to 164) | ||||
| Moderate | |||||
| 292 per 1000 | 214 per 1000 (193 to 239) | ||||